Hirudo medicinalis

a medical device

Hirudo Medicinalis

A MEDICAL DIVICE
Hirudo medicinalis

a medical device

A short introduction to Hirudo medicinalis

The name 'medicinal leech' comes from

its Latin name, Hirudo medicinalis. Among over 700 species of leeches worldwide, about 24 are found in Europe, but only one of them, Hirudo medicinalis , representing less than half a percent of the entire leech population is used in human medicine. The practice of using leeches for therapeutic bloodletting likely dates back to the Stone Age, where it was believed that they could help expel the body of demons and negative energies blamed as a cause of an illness. It’s not surprising. This is how these traditional remedies, often effective, were understood within the context of time. This way medicinal leeches have been used in various forms of tribal prehistoric medicine for millennia. 

Written historical sources of leech

therapy dates back to the dawn of human civilisation, highlighting its long-standing significance in the traditional healing systems around the globe. In Egypt, as early as 1500 years before Christ, the records from the Ebers Papyrus explain how leeches were applied for various ailments. Greek physician Galen and Hippocrates, often regarded as the father of our Western conventional medicine, described the use of leeches for treating headaches and inflammations. One of the most sophisticated systems of leech therapy is found in Ayurveda, which originated over 5,000 years ago during the times of ancient Indian saints and sages. The practice known as Jalaukaavacharana involves the therapeutic application of leeches for blood detoxification and the balancing of doshas within the human physical body, revealing a broader Hinduistic appreciation for Divine Intelligence and the remedies found in His/Her Creation.

But the height of medicinal leech usage

took place closer to our modern times, here in Central Europe. In the 18th and 19th centuries, France alone was using about 100 million leeches annually. Their application became widespread for a variety of ailments, including hypertension, blood disorders, and the rapidly evolving field of surgery, with the practice being led by none other than King Louis XVI himself. However, after 1830, with the rise of scientific thought and modern methods of chemical synthesis, as pharmaceutical drugs became more prevalent, the popularity of leeches began to wane…

It lasted until 1884, when John Berry

Haycraft, a British physician and professor of physiology, made a significant discovery: the blood consumed by leeches did not clot or spoil in their digestive systems. This was revolutionary. Allopathic medicine at that time had no pharmaceutical solutions for the coagulative processes occurring in the human circulatory system. Sadly, Haycraft’s groundbreaking research went largely unnoticed in the medical community, which pure intensions were progressively capitulating to the pressures of the emerging pharmaceutical industry that prioritised profit. The leech couldn’t be patented.

About 70 years later, in the late 1950s,

another independent researcher, Professor Friedrich Markwardt of the University of Pennsylvania, isolated a pure anticoagulant that was responsible for Haycraft’s observation. Known as hirudin, this small but potent peptide was poised to reshape the future of entire medicine. Since then, more than a hundred new organic compounds with complex structures and valuable therapeutic properties have been identified in Hirudo medicinalis ‘ saliva. These discoveries have sparked renewed interest in leeches among leading medical research centers, clinics, and hospitals exploring innovative treatment methods around the world.

The field of pharmacology has greatly

benefited from these findings too, leading to the development of synthetic drugs that mirror the mechanisms of these bio-compounds. Lepirudin and bivalirudin, anticoagulants that mimic hirudin, are used to prevent blood clots in patients at risk of stroke or heart attack. Argatroban, a direct thrombin inhibitor serves as an alternative anticoagulant. Additionally, researchers are investigating other bioactive peptides, that could enhance wound healing and improve therapeutic outcomes in other various medical conditions.

Today hospitals in the United States,

Germany, Poland, France, India, Russia, Israel and the Netherlands use leeches for various medical applications, including reconstructive surgery and the management of difficult wounds. As scientists continue to explore the medical properties of leech-derived substances, the potential for innovative drug therapies and therapeutic applications continues to expand. Certainly, the story that has remained unlistened for far too long is finally being heard. And there is so much more of this revolution yet to happen.

A short introduction to Hirudo medicinalis

The name "medicinal leech" comes from its Latin name, Hirudo medicinalis.

Among over 700 species of leeches worldwide, about 24 are found in Europe, but only one of them, Hirudo medicinalis, representing less than half a percent of the entire leech population is used in human medicine. The practice of using leeches for therapeutic bloodletting likely dates back to the Stone Age, where it was believed that they could help expel the body of demons and negative energies blamed as a cause of an illness. It’s not surprising. This is how these traditional remedies, often effective, were understood within the context of time. This way medicinal leeches have been used in various forms of tribal prehistoric medicine for millennia. 

Written historical sources of leech therapy

date back to the dawn of human civilisation, highlighting its long-standing significance in the traditional healing systems around the globe. In Egypt, as early as 1500 years before Christ, the records from the Ebers Papyrus explain how leeches were applied for various ailments. Greek physician Galen and Hippocrates, often regarded as the father of our Western conventional medicine, described the use of leeches for treating headaches and inflammations. One of the most sophisticated systems of leech therapy is found in Ayurveda, which originated over 5,000 years ago during the times of ancient Indian saints and sages. The practice known as Jalaukaavacharana involves the therapeutic application of leeches for blood detoxification and the balancing of doshas within the human physical body, revealing a broader Hinduistic appreciation for Divine Intelligence and the remedies found in His/Her Creation.

But the height of medicinal leech usage took place

closer to our modern times, here in Central Europe. In the 18th and 19th centuries, France alone was using about 100 million leeches annually. Their application became widespread for a variety of ailments, including hypertension, blood disorders, and the rapidly evolving field of surgery, with the practice being led by none other than King Louis XVI himself. However, after 1830, with the rise of scientific thought and modern methods of chemical synthesis, as pharmaceutical drugs became more prevalent, the popularity of leeches began to wane…

It lasted until 1884, when John Berry Haycraft,

a British physician and professor of physiology, made a significant discovery: the blood consumed by leeches did not clot or spoil in their digestive systems. This was revolutionary. Allopathic medicine at that time had no pharmaceutical solutions for the coagulative processes occurring in the human circulatory system. Sadly, Haycraft’s groundbreaking research went largely unnoticed in the medical community, which pure intensions were progressively capitulating to the pressures of the emerging pharmaceutical industry that prioritised profit. The leech couldn’t be patented.

Over 70 years later, in the late 1950s,

another independent researcher, Professor Friedrich Markwardt of the University of Pennsylvania, isolated a pure anticoagulant that was responsible for Haycraft’s observation. Known as hirudin, this small but potent peptide was poised to reshape the future of entire medicine. Since then, more than a hundred new organic compounds with complex structures and valuable therapeutic properties have been identified in Hirudo medicinalis ‘ saliva. These discoveries have sparked renewed interest in leeches among leading medical research centers, clinics, and hospitals exploring innovative treatment methods around the world.

The field of pharmacology has greatly benefited from these findings too,

leading to the development of synthetic drugs that mirror the mechanisms of these bio-compounds. Lepirudin and bivalirudin, anticoagulants that mimic hirudin, are used to prevent blood clots in patients at risk of stroke or heart attack. Argatroban, a direct thrombin inhibitor serves as an alternative anticoagulant. Additionally, researchers are investigating other bioactive peptides, that could enhance wound healing and improve therapeutic outcomes in other various medical conditions.

Today hospitals in the United States, Germany, Poland,

France, India, Russia, Israel and the Netherlands utilise leeches for various medical applications, including reconstructive surgery and the management of difficult wounds. As scientists continue to explore the medical properties of leech-derived substances, the potential for innovative drug therapies and therapeutic applications continues to expand. Certainly, the story that has remained unlistened for far too long is finally being heard. And there is so much more of this revolution still to happen.

What is Hirudotherapy?

Dating back thousands of years and recognised in numerous ancient civilisations around the globe for its extraordinary healing properties, hirudotherapy is a therapeutic process that employs medicinal leeches for medical purposes.

The medicinal leech is truly a masterpiece of evolution.

Having adapted over time to thrive in diverse environments, these remarkable creatures have developed an array of bioactive compounds being synthesised in their salivary glands which are essential for their feeding and survival. These compounds not only provide analgesic properties, which act as natural painkillers, allowing leeches to feed on their hosts almost undetectably, but they also ensure the fluidity of the host’s blood through powerful anticoagulant effects.

These exact mechanisms are utilised during the hirudotherapy treatment.

The application of medicinal leeches initiates a complex interaction between human blood and leech saliva that takes advantage of their unique physiological properties for significant pharmacological effects.

How does it work?

One of the most notable components of leech saliva, hirudin, is a potent anticoagulant that plays a critical role in preventing blood clotting. Hirudin inhibits thrombin, a key enzyme involved in the blood coagulation cascade, thereby providing a continuous flow of blood at the site of attachment. This sustained blood flow not only allows the leeches to feed effectively but as a ‘side effect’ also enhances the delivery of oxygen and nutrients to the surrounding tissues, which is essential for any process of healing.

In addition to hirudin, leech saliva comprises various enzymes and peptides that contribute to its therapeutic efficacy. One of them, hyaluronidase, breaks down hyaluronic acid in the extracellular matrix, improving tissue permeability and enhancing the diffusion of nutrients to the affected areas. This particular process finds special application in cosmetic hirudotherapy, nourishing deeper skin structures, smoothing wrinkles, and improving the elasticity of scarred tissues.

The combined action of bioactive substances in leech saliva not only enhances circulation and supports the reoxygenation of hypoxic (unoxygenated) tissues but also facilitates essential reparative processes vital for effective recovery. This makes hirudotherapy particularly beneficial for managing difficult wounds, post-surgical recovery, and transplant adaptation where blood flow is compromised and oxygen delivery is insufficient, resulting in prolonged healing and an increased risk of infection or transplant rejection. By enhancing local circulation and, consequently, oxygenation, nutrient delivery, and cellular metabolism, hirudotherapy significantly accelerates the restoration of tissue integrity and its function.

What is Hirudotherapy?

Dating back thousands of years and recognised in numerous ancient civilisations around the globe for its extraordinary healing properties, hirudotherapy is a therapeutic process that employs medicinal leeches for medical purposes.

The medicinal leech is truly a masterpiece of evolution.

Having adapted over time to thrive in diverse environments, these remarkable creatures have developed an array of bioactive compounds being synthesised in their salivary glands which are essential for their feeding and survival. These compounds not only provide analgesic properties, which act as natural painkillers, allowing leeches to feed on their hosts almost undetectably, but they also ensure the fluidity of the host’s blood through powerful anticoagulant effects.

These exact mechanisms are utilised during the hirudotherapy treatment.

The application of medicinal leeches initiates a complex interaction between human blood and leech saliva that takes advantage of their unique physiological properties for significant pharmacological effects.

How does it work?

One of the most notable components of leech saliva, hirudin, is a potent anticoagulant that plays a critical role in preventing blood clotting. Hirudin inhibits thrombin, a key enzyme involved in the blood coagulation cascade, thereby providing a continuous flow of blood at the site of attachment. This sustained blood flow not only allows the leeches to feed effectively but as a ‘side effect’ also enhances the delivery of oxygen and nutrients to the surrounding tissues, which is essential for any process of healing.

In addition to hirudin, leech saliva comprises various enzymes and peptides that contribute to its therapeutic efficacy. One of them, hyaluronidase, breaks down hyaluronic acid in the extracellular matrix, improving tissue permeability and enhancing the diffusion of nutrients to the affected areas. This particular process finds special application in cosmetic hirudotherapy, nourishing deeper skin structures, smoothing wrinkles, and improving the elasticity of scarred tissues.

The combined action of bioactive substances in leech saliva not only enhances circulation and supports the reoxygenation of hypoxic (unoxygenated) tissues but also facilitates essential reparative processes vital for effective recovery. This makes hirudotherapy particularly beneficial for managing difficult wounds, post-surgical recovery, and transplant adaptation where blood flow is compromised and oxygen delivery is insufficient, resulting in prolonged healing and an increased risk of infection or transplant rejection. By enhancing local circulation and, consequently, oxygenation, nutrient delivery, and cellular metabolism, hirudotherapy significantly accelerates the restoration of tissue integrity and its function.

Benefits of hirudotherapy

The medicinal leech is not a universal remedy for all ailments, but its efficacy is medically 

proven in various specific health conditions:

Pain management in osteoarthritis and rheumatoid arthritis

Post-surgical recovery and transplantology adaptation

Carpal tunnel syndrome

Migraines, headaches, and vertigo

Post-COVID syndrome

   Allergies

Inflammations

   Female reproductive system diseases and infertility

Depression

Kidney diseases 

Raynaud’s phenomenon

Fibromyalgia

Impotence

Hypertension and hypotension

Varicose veins, Spider veins and Hemorrhoids

Sinusitis

Heart diseases and pains

Cataract surgery recovery and other eye diseases

Gastrointestinal diseases

Bunions

Strengthening immune system

Skin disorders (dermatitis, psoriasis, vitiligo)

Herpes zoster

Diabetic wound management

Neuropathy

Lyme disease

Injuries

Benefits of Hirudotherapy

The medicinal leech is not a universal remedy for all ailments, but its efficacy is medically proven in various specific health conditions:

Migraines, headaches, and vertigo

Post-COVID syndrome

Allergies

Inflammations

Female reproductive system diseases and infertility

Depression

Weak kidneys and kidney diseases 

Raynaud’s phenomenon

Fibromyalgia

Impotence

Pain management in osteoarthritis and rheumatoid arthritis

Hypertension and hypotension

Nerve compression and regeneration

Sinusitis

Varicose veins, Spider veins and Hemorrhoids

Heart diseases and pains

Cataract surgery recovery and other eye diseases

Gastrointestinal diseases

Bunions

Strengthening immune system

Skin disorders (dermatitis, psoriasis, vitiligo)

Herpes zoster

Diabetic wound management

Neuropathy

Post-surgical recovery and transplantology adaptation

Lyme disease

Injuries

How should i get prepared for the medicinal leeches application?

Consult your medications

Inform me about any medications you are currently taking. In consultation with your doctor, you may be advised to temporarily stop taking anticoagulant medications or other drugs that could affect bleeding for a few days prior to the leeches application. In some cases, you may also be asked to undergo a course of antibiotics to minimise the risk of infection.

Get well informed

Take your time and familiarise yourself with what to expect during and after the treatment, including potential sensations (biting, tingling) and possible side effects. You will find all the necessary information on this website.

Follow the diet

Stay well hydrated. Avoid alcohol, sugar and excessive caffeine for at least 3 days before the application. Consider adding alkalising foods and drinks to your diet, as well as antibacterial herbs such as andrographis paniculata and oregano oil. It’s advisable to continue this regimen for as long as possible before the application and until any side effects have completely faded away after.

Have only a water shower

Do not use any perfumes, creams or cleaning products, such as shower gels or soaps, on the area intended for application for at least 24 hours prior to the treatment. The leeches do not tolerate most artificial substances and will not want to attach.

Dress appropriately

Wear comfortable clothing that allows easy access to the treatment area. Consider that the application will involve bleeding, so you might want to wear old clothes or a protective covering.

Plan for aftercare

There is bleeding after the leeches have finished feeding. Immediately after the application you will be taken care of appropriately, but your dressings will soon need to be refreshed. It’s good to have someone to help and best to take a day off.

How should i get prepared for the medicinal leeches application?

Consult your medications

Inform me about any medications you are currently taking. In consultation with your doctor, you may be advised to temporarily stop taking anticoagulant medications or other drugs that could affect bleeding for a few days prior to the leeches application. In some cases, you may also be asked to undergo a course of antibiotics to minimise the risk of infection.

Get well informed

Take your time and familiarise yourself with what to expect during and after the treatment, including potential sensations (biting, tingling) and possible side effects. You will find all the necessary information on this website.

Follow the diet

Stay well hydrated. Avoid alcohol, sugar and excessive caffeine for at least 3 days before the application. Consider adding alkalising foods and drinks to your diet, as well as antibacterial herbs such as andrographis paniculata and oregano oil. It’s advisable to continue this regimen for as long as possible before the application and until any side effects have completely faded away after.

Have only a water shower

Do not use any perfumes, creams or cleaning products, such as shower gels or soaps, on the area intended for application for at least 24 hours prior to the treatment. The leeches do not tolerate most artificial substances and will not want to attach.

Dress appropriately

Wear comfortable clothing that allows easy access to the treatment area. Consider that the application will involve bleeding, so you might want to wear old clothes or a protective covering.

Plan for aftercare

There is bleeding after the leeches have finished feeding. Immediately after the application you will be taken care of appropriately, but your dressings will soon need to be refreshed. It’s good to have someone to help and best to take a day off.

How does a medicinal leech application look like?

Disinfection

Disinfection of medicinal leeches is a critical step in ensuring their safety and efficacy for medical use. As living organisms, the leeches cannot be exposed to strong disinfecting agents such as alcohol, which could injure them, provoke vomiting, or even cause death. To provide maximal safety, a leech is immersed in copper-ionised water with a pinch of turmeric powder for about 20 minutes before its application. As natural and non-toxic, both substances are recognised for their antimicrobial properties and do not harm the leech.

Attachment

A leech is delivered to a designated area on the body, where it attaches to the skin using both ends. Leeches have suckers at their mouth as well as at their tail; the anterior sucker is used to attach to the host, while the posterior sucker acts as an anchor. They can extend their bodies to create a strong grip, allowing them to resist pulling forces of up to several kilograms. The number of leeches attached depends on the specific health complaints and the area of application. To maximise safety, it is common practice to start with a single leech during the initial treatment session.

Cutting and primary anesthetic injection

When leeches begin to feed, they use their three jaws, shaped like razor blades, to make small incisions in the skin of their host. This is often painless or feels like a mosquito bite, thanks to the leech’s anesthetic secretions.

Sucking blood and salivary secretions

The saliva of medicinal leeches contains a cocktail of powerful bioactive substances. So far, over one hundred different biocompounds have been identified, including anticoagulants such as hirudin, which prevents the host’s blood from coagulating and ensures a steady, continuous flow into their mouths; antiplatelet agents like prostaglandin E1, which further inhibit clotting; and histamine, which enhances blood flow by dilating blood vessels—all of which with remarkable therapeutic abilities. Their cascade properties ensure a slow, gradual impact on the structure of human blood, as the primarily injected complex substances break down over time into other biochemical compounds. During a single feeding session lasting from 30 minutes to an hour, a leech can consume several times its body weight in blood.

Filtering and excretion

During and after feeding, leeches demonstrate the ability to filter out essential components from the blood. This filtering process enables them to extract not only plasma but also vital nutrients. As the leech sucks blood from its host, it also ingests surrounding lymph, which is primarily composed of water, electrolytes, and proteins. The leech selectively absorbs the blood while getting rid of excess fluid, maximising the nutritional value of what it consumes and minimising the volume of fluid it retains.

What does aftercare look like?

Monitoring the bite sites

Observe the bite sites for signs of excessive bleeding, swelling, redness, or infection. It is normal for some bleeding to occur, since leeches secrete anticoagulants that prevent blood from clotting, as well as for itchiness, swelling, or redness to be experienced, due to the natural presence of Aeromonas bacteria residing on leech skin and in their gut, which can be transmitted during the application. If these reactions do not begin to subside within 48 hours, reach out for consultation. If there are any other concerning symptoms, such as fever or severe persistent bleeding, reach out immediately.

 

Managing bleeding

If excessive bleeding occurs, apply a pinch of powdered turmeric directly to the wound. Cover it with a cosmetic cotton pad and secure it with a plaster or bandage. Avoid using tight bandages that could restrict circulation. Do not pick at the scabs to avoid unnecessary infection or scarring. It takes time for them to drop off naturally.

Hygiene

Keep the bite sites clean and dry. Do not wash them under running water for a minimum of 24 hours after application and until the bleeding stops completely. You can gently clean around them using a wet piece of cotton or a cotton cosmetic pad with a little soap. Avoid scrubbing the areas. Do not apply any disinfecting agents, creams, ointments, or other topical treatments directly to the wound. You can use a natural soothing ointment or cream on the itchy or swollen areas around the bite site to help with irritation.

Avoiding irritants

Avoid swimming or soaking in baths until the bite sites have fully healed to prevent infection. Keep the area free of irritants, such as tight clothing or harsh chemicals.

Dietary considerations

Avoid substances that could affect blood clotting, such as aspirin and other nonsteroidal drugs or alcohol, for a period of 48 hours after treatment.

How does a medicinal leech application look like?

Disinfection

Disinfection of medicinal leeches is a critical step in ensuring their safety and efficacy for medical use. As living organisms, the leeches cannot be exposed to strong disinfecting agents such as alcohol, which could injure them, provoke vomiting, or even cause death. To provide maximal safety, a leech is immersed in copper-ionised water with a pinch of turmeric powder for about 20 minutes before its application. As natural and non-toxic, both substances are recognised for their antimicrobial properties and do not harm the leech.

Attachment

A leech is delivered to a designated area on the body, where it attaches to the skin using both ends. Leeches have suckers at their mouth as well as at their tail; the anterior sucker is used to attach to the host, while the posterior sucker acts as an anchor. They can extend their bodies to create a strong grip, allowing them to resist pulling forces of up to several kilograms. The number of leeches attached depends on the specific health complaints and the area of application. To maximise safety, it is common practice to start with a single leech during the initial treatment session.

Cutting and primary anesthetic injection

When leeches begin to feed, they use their three jaws, shaped like razor blades, to make small incisions in the skin of their host. This is often painless or feels like a mosquito bite, thanks to the leech’s anesthetic secretions.

Sucking blood and salivary secretions

The saliva of medicinal leeches contains a cocktail of powerful bioactive substances. So far, over one hundred different biocompounds have been identified, including anticoagulants such as hirudin, which prevents the host’s blood from coagulating and ensures a steady, continuous flow into their mouths; antiplatelet agents like prostaglandin E1, which further inhibit clotting; and histamine, which enhances blood flow by dilating blood vessels—all of which with remarkable therapeutic abilities. Their cascade properties ensure a slow, gradual impact on the structure of human blood, as the primarily injected complex substances break down over time into other biochemical compounds. During a single feeding session lasting from 30 minutes to an hour, a leech can consume several times its body weight in blood.

Filtering and excretion

During and after feeding, leeches demonstrate the ability to filter out essential components from the blood. This filtering process enables them to extract not only plasma but also vital nutrients. As the leech sucks blood from its host, it also ingests surrounding lymph, which is primarily composed of water, electrolytes, and proteins. The leech selectively absorbs the blood while getting rid of excess fluid, maximising the nutritional value of what it consumes and minimising the volume of fluid it retains.

What does aftercare look like?

Monitoring the bite sites

Observe the bite sites for signs of excessive bleeding, swelling, redness, or infection. It is normal for some bleeding to occur, since leeches secrete anticoagulants that prevent blood from clotting, as well as for itchiness, swelling, or redness to be experienced, due to the natural presence of Aeromonas bacteria residing on leech skin and in their gut, which can be transmitted during the application. If these reactions do not begin to subside within 48 hours, reach out for consultation. If there are any other concerning symptoms, such as fever or severe persistent bleeding, reach out immediately.

 

Managing bleeding

If excessive bleeding occurs, apply a pinch of powdered turmeric directly to the wound. Cover it with a cosmetic cotton pad and secure it with a plaster or bandage. Avoid using tight bandages that could restrict circulation. Do not pick at the scabs to avoid unnecessary infection or scarring. It takes time for them to drop off naturally.

 

Hygiene

Keep the bite sites clean and dry. Do not wash them under running water for a minimum of 24 hours after application and until the bleeding stops completely. You can gently clean around them using a wet piece of cotton or a cotton cosmetic pad with a little soap. Avoid scrubbing the areas. Do not apply any disinfecting agents, creams, ointments, or other topical treatments directly to the wound. You can use a natural soothing ointment or cream on the itchy or swollen areas around the bite site to help with irritation.

Avoiding irritants

Avoid swimming or soaking in baths until the bite sites have fully healed to prevent infection. Keep the area free of irritants, such as tight clothing or harsh chemicals.

    Dietary considerations

    Avoid substances that could affect blood clotting, such as aspirin and other nonsteroidal drugs or alcohol, for a period of 48 hours after treatment.

    Pricing table

    A various number of leeches is applied in a single session.

    Each application consists of a base price plus the number of leeches applied.

    Pricing table

    A various number of leeches is applied in a single session.

    Each application consists of a base price plus the number of leeches applied.

    Frequently Asked Questions

    Is 'Medicinalis' qualified and legally authorised to perform hirudotherapy?

    ‘Medicinalis’ possesses all the necessary knowledge, skills, and legal authorisation to carry out hirudotherapy. I am a licensed hirudotherapist, trained in both the theoretical and practical aspects of leech therapy. My credentials include accreditations from the British Association of Hirudotherapy and the Saint Petersburg Hirudologist Association, along with permission number RIS 2.02/00221/2021.

    What are the contraindications for medicinal leeches treatment?

    Contraindications for medicinal leech treatment include recognised hypersensitivity or allergy to leech saliva, active bleeding disorders (such as hemophilia or thrombocytopenia), significant anemia, and the use of pharmacological anticoagulant therapies such as warfarin, dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis), edoxaban (Savaysa), enoxaparin (Lovenox), and fondaparinux (Arixtra).

    Additionally, immunosuppressive therapies and impaired immune response (cancer, severe infections, or skin lesions in the treatment area), nonsteroidal anti-inflammatory drugs (eg, ibuprofen, aspirin, naproxen, meloxicam, kiprofen) as well as children below 16 years of age, pregnant or breastfeeding women and women during menstruation, are also considered unsuitable circumstances for leech application. However, these factors are not categorised as definitive contraindications and may be taken into account with additional precautions.

    What are the common risks related to the medicinal leeches' application?

    Hirudotherapy is mostly safe but can involve risks, such as bacterial infections, hypersensitivity to leech saliva, and allergic reactions. The leech microbiome plays a significant role in its health and physiology; therefore, it is important to understand that the transmission of bacteria residing on the leech’s skin and in its gut is an inevitable and natural consequence of leech application. A healthy immune system fights off these infections within a couple of days. In some cases, antibiotics may be prescribed to anticipate and prevent complications.

    To ensure and maximise safety, the first introductory session involves only a single leech.

    What are the potential side effects of medicinal leeches application?

    The most frequently occurring side effects of hirudotherapy include infections caused by Aeromonas bacteria, which inhabit both the skin of the leeches and their digestive systems, as well as allergic reactions to leech saliva. These allergic reactions can manifest in a range of symptoms, from mild local irritation—such as itching, redness, or swelling—to more widespread effects that may involve nearby lymphatic nodes. Prolonged bleeding or bruising can occur, as the anticoagulants present in leech saliva can extend bleeding times significantly.

    How should I get prepared for the medicinal leeches application?
    • Inform me about any medications you are currently taking. In consultation with your doctor, you may be advised to temporarily stop taking anticoagulant medications or other drugs that could affect bleeding for a few days prior to the leeches application. In some cases, you may also be asked to undergo a course of antibiotics to minimise the risk of infection.
    • Take your time and familiarise yourself with what to expect during and after the treatment, including potential sensations (biting, tingling) and possible side effects.
    • Avoid alcohol, sugar and excessive caffeine for at least 3 days before the application.
    • Stay well hydrated.
    • Consider adding alkalising foods and drinks to your diet, as well as antibacterial herbs such as andrographis paniculata and oregano oil. It’s advisable to continue this regimen for as long as possible before the application and until any side effects have completely faded away after.
    • Have only a water shower. Do not use any perfumes or cleaning products, such as shower gels or soaps, on the area intended for application for at least 24 hours prior to the treatment.
    • Dress appropriately. Wear comfortable clothing that allows easy access to the treatment area. Consider that the application will involve bleeding, so you might want to wear old clothes or a protective covering.
    • Plan for aftercare, as there is bleeding after the leeches have finished feeding. Immediately after the application you will be taken care of appropriately, but your dressings will soon need to be refreshed. It’s good to have someone to help and best to take a day off.
    How soon can I follow with the second application?

    If there are no contraindications related to introducing one’s body to leech saliva, the second application can be administered the next day.

    What is the recommended time interval between two regular applications?

    Generally, it is suggested to wait about one week between sessions to allow the body to recover and to monitor the effects from the treatment.

    Can I develop tolerance to leech saliva?

    You might develop a tolerance to the medicaments found in leech saliva, which means your body may get used to these substances over time. As a result, you may notice a decrease in the effectiveness of the treatment, possibly requiring higher doses or more frequent sessions to achieve the same therapeutic results. This is especially relevant for those managing chronic pain, as you may find that to gain the same level of relief, your treatment needs increase as tolerance develops.

    However, it’s important to note that responses to prolonged systemic leech applications can vary greatly from person to person. Some patients may find they need to adjust their treatment plan over time due to changes in how effective the therapy is, while others may not experience much tolerance at all and can continue with the same frequency and dosage for an extended period without the therapeutic results being affected much.

    What can I expect after the application?

    After the application of leeches, you can expect mild but continuous bleeding (lasting up to 24 hours) at the site where they are attached, which is a normal reaction since leeches’ saliva prevents blood from clotting. The area may feel slightly swollen, warm, or tingly. Additionally, some bruising or redness may occur. It is important to keep the area clean to prevent infection. These effects are temporary and resolve within a few days.

    Where do medicinal leeches come from?

    Medicinal leeches are sourced from specific farms that breed and certify them for medical use. They are not collected from the wild. These farms maintain controlled environments throughout the entire growth process to ensure that the leeches are healthy and free from diseases and infections, making them suitable for therapeutic applications in medicine.

    What does aftercare look like?
    • Observe the bite sites for signs of excessive bleeding, swelling, redness, or infection. It is normal for some bleeding to occur, since leeches secrete anticoagulants that prevent blood from clotting, as well as for itchiness, swelling, or redness to be experienced, due to the natural presence of Aeromonas bacteria residing on leech skin and in their gut, which can be transmitted during the application. If these reactions do not begin to subside within 48 hours, reach out for consultation. If there are any other concerning symptoms, such as fever or severe persistent bleeding, reach out immediately.
    • If excessive bleeding occurs, apply a pinch of powdered turmeric directly to the wound. Cover it with a cosmetic cotton pad and secure it with a plaster or bandage. Avoid using tight bandages that could restrict circulation. Do not pick at the scabs to avoid unnecessary infection or scarring. It takes time for them to drop off naturally.
    • Keep the bite sites clean and dry. Do not wash them under running water for a minimum of 24 hours after application and until the bleeding stops completely. You can gently clean around them using a wet piece of cotton or a cotton cosmetic pad with a little soap. Avoid scrubbing the areas.
    • Do not apply any disinfecting agents, creams, ointments, or other topical treatments directly to the wound. You can use a natural soothing ointment or cream on the itchy or swollen areas around the bite site to help with irritation.
    • Avoid swimming or soaking in baths until the bite sites have fully healed to prevent infection.
    • Keep the area free of irritants, such as tight clothing or harsh chemicals.
    • Avoid substances that could affect blood clotting, such as aspirin and other nonsteroidal drugs or alcohol, for a period of 48 hours after treatment.
    Is leeches application painful?

    The application of leeches is generally not painful due to the anesthetic compounds present in their saliva. Most people experience sensations like a small pinch or sting when the leech attaches, similar to a mosquito bite.

    How many leeches will I need at a single session?

    The number of leeches required for a single session of hirudotherapy can vary depending on several factors, including the condition being treated, the patient’s body size, health status, and the area of application. The initial introductory session involves only a single leech, while a full-spectrum application consists of up to eight leeches.

    How many leech sessions will I need?

    The number of leech therapy sessions you need depends on various factors, such as your specific condition, its severity, and your individual response to the treatment. Generally, a single session can provide significant therapeutic response, but a series of sessions may be needed for optimal and lasting results.

    Can leeches be used alongside other treatments?

    Yes, leeches can be used alongside other treatments in certain medical contexts. Their use, particularly in procedures such as reconstructive surgery or the treatment of certain vascular issues, can complement other therapies. In some cases, leeches may be utilised in conjunction with pain management treatments, providing an additional avenue for relief by enhancing local blood flow and reducing swelling. Leeches can often be part of a broader treatment protocol that may include medications, physiotherapy, or other alternative therapies, although the specific combination is always decided on an individual basis, taking into consideration all the necessary aspects.

    Are medicinal leeches ever used again?

    Although leeches after their application could technically be reused on the same person, ‘Medicinalis’ uses new leeches for every treatment to ensure safety, practicality, and efficacy. 

    What happens to the leeches after their applications?

    In the Netherlands, the disposal of medical leeches is subject to regulations governing the treatment of living organisms, particularly in medical contexts. When leeches have been used for therapeutic applications and are no longer suitable for reuse, they are disposed of in a humane manner that minimises their suffering and are treated appropriately as biomedical waste.

    Is Hirudo medicinalis leech a parasite?

    Hirudo medicinalis, a medicinal leech, rather than a parasite can be classified as symbiotic in medical circumstances. While it does feed on the blood of its host, it is also used in medicine for its unique beneficial properties. The leech’s saliva contains anticoagulants and vasodilators that enhance blood flow and reduce clotting, aiding in recovery and healing. In this context, Hirudo medicinalis demonstrates a symbiotic relationship with its host by providing therapeutic benefits rather than causing harm.

    Evolution in the Service of Medicine

    Frequently Asked Questions

    Is 'Medicinalis' qualified and legally authorised to perform hirudotherapy?

    Yes, ‘Medicinalis’ possesses all the necessary knowledge, skills, and legal authorisation to carry out hirudotherapy. I am a licensed hirudotherapist, trained in both the theoretical and practical aspects of leech therapy. My credentials include accreditations from the British Association of Hirudotherapy and the Saint Petersburg Hirudologist Association, along with permission number RIS 2.02/00221/2021.

    What are the contraindications for medicinal leeches treatment?

    Contraindications for medicinal leech treatment include recognised hypersensitivity or allergy to leech saliva, active bleeding disorders (such as hemophilia or thrombocytopenia), significant anemia, and the use of pharmacological anticoagulant therapies such as warfarin, dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis), edoxaban (Savaysa), enoxaparin (Lovenox), and fondaparinux (Arixtra).

    Additionally, immunosuppressive therapies and impaired immune response (cancer, severe infections, or skin lesions in the treatment area), nonsteroidal anti-inflammatory drugs (eg, ibuprofen, aspirin, naproxen, meloxicam, kiprofen) as well as children below 16 years of age, pregnant or breastfeeding women and women during menstruation, are also considered unsuitable circumstances for leech application. However, these factors are not categorised as definitive contraindications and may be taken into account with additional precautions.

    What are the common risks associated with hirudotherapy?

    Hirudotherapy is mostly safe but can involve risks, such as bacterial infections, hypersensitivity to leech saliva, and allergic reactions. The leech microbiome plays a significant role in its health and physiology; therefore, it is important to understand that the transmission of bacteria residing on the leech’s skin and in its gut is an inevitable and natural consequence of leech application. A healthy immune system fights off these infections within a couple of days. In some cases, antibiotics may be prescribed to anticipate and prevent complications.

    To ensure and maximise safety, the first introductory session involves only a single leech.

    What are the potential side effects of medicinal leeches application?

    The most frequently occurring side effects of hirudotherapy include infections caused by Aeromonas bacteria, which inhabit both the skin of the leeches and their digestive systems, as well as allergic reactions to leech saliva. These allergic reactions can manifest in a range of symptoms, from mild local irritation—such as itching, redness, or swelling—to more widespread effects that may involve nearby lymphatic nodes. Prolonged bleeding or bruising can occur, as the anticoagulants present in leech saliva can extend bleeding times significantly.

    How should I get prepared for the medicinal leeches application?
    • Inform me about any medications you are currently taking. In consultation with your doctor, you may be advised to temporarily stop taking anticoagulant medications or other drugs that could affect bleeding for a few days prior to the leeches application. In some cases, you may also be asked to undergo a course of antibiotics to minimise the risk of infection.
    • Take your time and familiarise yourself with what to expect during and after the treatment, including potential sensations (biting, tingling) and possible side effects.
    • Avoid alcohol, sugar and excessive caffeine for at least 3 days before the application.
    • Stay well hydrated.
    • Consider adding alkalising foods and drinks to your diet, as well as antibacterial herbs such as andrographis paniculata and oregano oil. It’s advisable to continue this regimen for as long as possible before the application and until any side effects have completely faded away after.
    • Have only a water shower. Do not use any creams, perfumes or cleaning products, such as shower gels or soaps, on the area intended for application for at least 24 hours prior to the treatment.
    • Dress appropriately. Wear comfortable clothing that allows easy access to the treatment area. Consider that the application will involve bleeding, so you might want to wear old clothes or a protective covering.
    • Plan for aftercare, as there is bleeding after the leeches have finished feeding. Immediately after the application you will be taken care of appropriately, but your dressings will soon need to be refreshed. It’s good to have someone to help and best to take a day off.
    How soon can I follow with the second application?

    If there are no contraindications related to introducing one’s body to leech saliva, the second application can be administered the next day.

    What is the recommended time interval between two regular applications?

    Generally, it is suggested to wait about one week between sessions to allow the body to recover and to monitor the effects from the treatment.

    Can I develop tolerance to leech saliva?

    You might develop a tolerance to the medicaments found in leech saliva, which means your body may get used to these substances over time. As a result, you may notice a decrease in the effectiveness of the treatment, possibly requiring higher doses or more frequent sessions to achieve the same therapeutic results. This is especially relevant for those managing chronic pain, as you may find that to gain the same level of relief, your treatment needs increase as tolerance develops.

    However, it’s important to note that responses to prolonged systemic leech applications can vary greatly from person to person. Some patients may find they need to adjust their treatment plan over time due to changes in how effective the therapy is, while others may not experience much tolerance at all and can continue with the same frequency and dosage for an extended period without the therapeutic results being affected much.

    What can I expect after the application?

    After the application of leeches, you can expect mild but continuous bleeding (lasting up to 24 hours) at the site where they are attached, which is a normal reaction since leeches’ saliva prevents blood from clotting. The area may feel slightly swollen, warm, or tingly. Additionally, some bruising or redness may occur. It is important to keep the area clean to prevent infection. These effects are temporary and resolve within a few days.

    Where do medicinal leeches come from?

    Medicinal leeches are sourced from specific farms that breed and certify them for medical use. They are not collected from the wild. These farms maintain controlled environments throughout the entire growth process to ensure that the leeches are healthy and free from diseases and infections, making them suitable for therapeutic applications in medicine.

    Is leeches application painful?

    The application of leeches is generally not painful due to the anesthetic compounds present in their saliva. Most people experience sensations like a small pinch or sting when the leech attaches, similar to a mosquito bite.

    What does aftercare look like?
    • Observe the bite sites for signs of excessive bleeding, swelling, redness, or infection. It is normal for some bleeding to occur, since leeches secrete anticoagulants that prevent blood from clotting, as well as for itchiness, swelling, or redness to be experienced, due to the natural presence of Aeromonas bacteria residing on leech skin and in their gut, which can be transmitted during the application. If these reactions do not begin to subside within 48 hours, reach out for consultation. If there are any other concerning symptoms, such as fever or severe persistent bleeding, reach out immediately.
    • If excessive bleeding occurs, apply a pinch of powdered turmeric directly to the wound. Cover it with a cosmetic cotton pad and secure it with a plaster or bandage. Avoid using tight bandages that could restrict circulation.
    • Do not pick at the scabs to avoid unnecessary infection or scarring. It takes time for them to drop off naturally.
    • Keep the bite sites clean and dry. Do not wash them under running water for a minimum of 24 hours after application and until the bleeding stops completely. You can gently clean around them using a wet piece of cotton or a cotton cosmetic pad with a little soap. Avoid scrubbing the areas.
    • Do not apply any disinfecting agents, creams, ointments, or other topical treatments directly to the wound. You can use a natural soothing ointment or cream on the itchy or swollen areas around the bite site to help with irritation.
    • Avoid  swimming or soaking in baths until the bite sites have fully healed to prevent infection.
    • Keep the area free of irritants, such as tight clothing or harsh chemicals.
    • Avoid substances that could affect blood clotting, such as aspirin and other nonsteroidal drugs or alcohol, for a period of 48 hours after treatment.
    How many leeches will I need at a single session?

    The number of leeches required for a single session of hirudotherapy can vary depending on several factors, including the condition being treated, the patient’s body size, health status, and the area of application. The initial introductory session involves only a single leech, while a full-spectrum application consists of up to eight leeches.

    How many leech sessions will I need?

    The number of leech therapy sessions you need depends on various factors, such as your specific condition, its severity, and your individual response to the treatment. Generally, a single session can provide significant therapeutic response, but a series of sessions may be needed for optimal and lasting results.

    Can leeches be used alongside other treatments?

    Yes, leeches can be used alongside other treatments in certain medical contexts. Their use, particularly in procedures such as reconstructive surgery or the treatment of certain vascular issues, can complement other therapies. In some cases, leeches may be utilised in conjunction with pain management treatments, providing an additional avenue for relief by enhancing local blood flow and reducing swelling. Leeches can often be part of a broader treatment protocol that may include medications, physiotherapy, or other alternative therapies, although the specific combination is always decided on an individual basis, taking into consideration all the necessary aspects.

    Are medicinal leeches ever used again?

    Although leeches after their application could technically be reused on the same person, ‘Medicinalis’ uses new leeches for every treatment to ensure safety, practicality, and efficacy. 

    What happens to the leeches after their applications?

    In the Netherlands, the disposal of medical leeches is subject to regulations governing the treatment of living organisms, particularly in medical contexts. When leeches have been used for therapeutic applications and are no longer suitable for reuse, they are disposed of in a humane manner that minimises their suffering and are treated appropriately as biomedical waste.

    Is 'Hirudo medicinalis' leech a parasite?

    Hirudo medicinalis, a medicinal leech, rather than a parasite can be classified as symbiotic in medical circumstances. While it does feed on the blood of its host, it is also used in medicine for its unique beneficial properties. The leech’s saliva contains anticoagulants and vasodilators that enhance blood flow and reduce clotting, aiding in recovery and healing. In this context, Hirudo medicinalis demonstrates a symbiotic relationship with its host by providing therapeutic benefits rather than causing harm.